EXPERIENCING THE IMPOSSIBLE AND CREATIVITY: A TARGETED LITERATURE REVIEW



Chronopharmacology of immune-related diseases

Clock genes, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN), control various circadian rhythms in many biological processes such as physiology and behavior.Clock gene regulates many diseases such as cancer, immunological dysfunction, metabolic syndrome and sleep disorders etc.Chronotherapy is especially relevant, when the ri

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Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved?

To provide evidence for the protective role of inorganic nitrite against acute ischaemia and reperfusion-induced ventricular arrhythmias in a large animal model.Dogs, anaesthetized with chloralose and urethane, were administered intravenously with sodium nitrite (0.2 µmol kg(-1) min(-1)) in two protocols.In protocol 1 nitrite was infused 10 min pr

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